徐从军 博士 副教授 博士研究生导师
邮箱：[email protected]；[email protected]
2018年毕业于沈阳药科大学获得博士学位，随后进入中山大学优德
进行博士后研究工作，2021年11月通过高层次人才引进 到海南大学工作。
1.教育背景与科研经历
2018.09—2021.08，中山大学， 优德
，博士后；
2015.09—2018.06，沈阳药科大学， 制药工程，博士；
2012.09—2015.06，沈阳药科大学， 药物化学，硕士；
2008.09—2012.06，长春工业大学， 制药工程，学士；
2.研究领域
海洋来源抗AD活性先导结构修饰与成药性优化；
铁死亡调控分子发现与活性评价
3.教学与论著
本科生《药物化学》《药物化学实验》硕士生《药物化学专论》《药物分子设计》
2024年获海南省青年教师教学竞赛三等奖；
参与编写全国高等医药院校药学类专业研究生规划教材《药物合成技术》。
4.学术兼职
The Innovation Medicine青年编委，Pharmaceutical Science Advances青年编委，《中国药物化学杂志》青年编委
5. 代表项目
1）国家自然科学基金青年项目，82204193，30万元，主持；
2）国家自然科学基金地区项目，82560683，31万元，主持；
3）广东省基础与应用基础研究基金区域联合基金，2020A1515110522，10万元，主持；
4）广东省自然科学基金面上项目，2022A1515012527，10万元，主持；
5）海南省自然科学基金面上项目，822MS052，8万元，主持；
6.代表性成果
1）Gu, S.; Yang, G.; Bian, H.; Yang, F.; Zhang, Y.; Huang, Y.; Su, R.; Zhang, H.; Zhao, X.; Liu, J.; Huang, S.; Huang, L.; Hou, B.*; Rao, Y.*; Xu, C.* Development of a Highly Selective Ferroptosis Inducer Targeting GPX4 with 2-Ethynylthiazole-4-carboxamide as Electrophilic Warhead. J. Med. Chem. 2025, 68, 3309-3323. (SCI, IF 6.8，中科院大类一区)；
2） Yang, A.; Gu, S.; Jiao, Z.; Feng, Y.; Sun, H.; Yang, G.; Gao, M.; Zeng, T.; Hou, B.; Huang, L.*; Wang, X.*; Xu, C.*; Luo, H. Discovery of 2-oxopiperazine derivatives as novel GPX4 inhibitors for the treatment of oral cancer. Chin. Chem. Lett. 2025, 112063. (SCI, IF 8.9，中科院大类一区)
3）Yang, F.; Fu, T.; Xiong, W.; Zhang, S.; Wang, J.; Shan, W.; Chen, X.; Chen, M.; Guo, Q.; Li, J.; Li, J.; Liu, J.; Liu, J.; Rao, Y.; Jiang, Z.*; Xu, C.*; Huang, L*. Discovery of marine-derived ent-atisane diterpenoid lead compounds targeting sEH for Alzheimer's disease therapy. Chin. Chem. Lett. 2025, 111773. (SCI, IF 8.9，中科院大类一区)
4）Huang, Y.; Liu, Q.; Li, J.; Cheng, M.; Su, R.; Jiao, Z.; Gu, S.; Wang, Q.; Wang, W.; Yang, F.; Rao, Y.; Huang, L.*; Gao, Y*.; Xu, C*. Design, synthesis, and induction of tumor ferroptosis activity of a novel FSP1 protein degrading agent. Eur. J. Med. Chem. 2026, 302, 118270. (SCI, IF 6.0，中科院一区)
5）Yang, F.; Guo, Q.; Chen, M.; Wang, W.; Chen, X.; Zhang, S.; Bian, H.; Li, J.; Jiao, Z.; Wang, Q.; Xiong, W.; Huang, Y.-y.*; Liu, Y.*; Xu, C*.; Huang, L*. Discovery of novel 2,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridine-7-one derivatives as PDE2 inhibitors with Alzheimer's disease therapeutic potential. Eur. J. Med. Chem. 2026, 302, 118302. (SCI, IF 6.0，中科院一区)
6）Huang, Z.#; Xu, C.#; Ding, Y.; Zeng, Z.; Lin, H.; Luo, Y.; Huang, Y.; Zhao, C.* A ROS/photo dual-responsive prodrug unimolecular micelle for boosted cancer immunotherapy. Asian J. Pharm. Sci. 2025, accepted. (SCI, IF 11.9，中科院一区)
7）Ma, R.; Fu, R.; Wang, Y.; Njobvu, K. M.; Fan, Y.; Yang, Z.; Chen, M.; Liu, F.; Jiang, Z.; Rao, Y.; Huang, L.; Xu, C.; Chen, J.; Liu, J. Discovery of novel rigid STING PROTAC degraders as potential therapeutics for acute kidney injury. Eur. J. Med. Chem. 2025, 290, 117539. (SCI, IF 6.0，中科院一区)
8）Fan, R.; Lu, X.; Xu, C.*; Wei, G*. Multidimensional regulation of the tumor microenvironment. The Innovation Medicine. 2025, 100166.
9）Yong Rao*#, Rui Su#, Chenyan Wu#, Xingxing Chai, Jinjian Li, Guanyu Yang, Junjie Wu, Tingting Fu, Zhongping Jiang, Zhikai Guo, Congjun Xu*, Ling Huang*, Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp. c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1α/XBP-1s axis and JNK signaling. Acta Pharmaceutica Sinica B, 2024, 14, 304-318. (SCI, IF 14.5000，中科院大类一区)
10）Xu, Congjun*; Han, Yufei; Xu, Sicong; Wang, Ruxin; Yue, Ming; Tian, Yu; Li, Xiaofan; Zhao, Yanfang*; Gong, Ping*; Design, synthesis and biological evaluation of new Axl kinase inhibitors containing 1,3,4-oxadiazole acetamide moiety as novel linker, European Journal of Medicinal Chemistry, 2020, 186: 111867. (SCI, IF 7.0878，中科院大类一区)；
11） Mingze Qin*, Yangyang Meng, Haoshen Yang, Lei Liu, Haotian Zhang, Simeng Wang, Chunyang Liu, Xia Wu, Di Wu, Ye Tian, Yunlei Hou, Yanfang Zhao, Yajing Liu, Congjun Xu*, Lihui Wang*, Discovery of 4-Arylindolines Containing a Thiazole Moiety as Potential Antitumor Agents Inhibiting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. Journal of Medicinal Chemistry, 2021, 64, 5519–5534 (SCI，IF 8.0385，中科院大类一区)；
12）Yifeng Shen#,Congjun Xu#, Jie Chen#, Zilin Guan, Yanjuan Huang, Zishan Zeng, Xiaoyu Xu, Xiaomin Tan, and Chunshun Zhao*. Photo-triggered self-adaptive “Nano-chameleon”：A Functionalized MOCs-based Drug Delivery Platform Promises high anti-tumor efficacy. Advanced Healthcare Materials. 2021, 10, 2100676. (SCI，IF 11.0926，中科院大类一区)；
13）Congjun Xu‡, Zhanghong Xiao‡, Jing Wang, Hualu Lai, Tao Zhang, Zilin Guan, Meng Xia, Meixu Chen, Lingling Ren, yuanfeng He,Yuqi Gao, Chunshun Zhao*. Discovery of A Potent Glutathione Peroxidase 4 Inhibitor as Selective Ferroptosis Inducer. Journal of Medicinal Chemistry, 2021, 64,13312−13326. (SCI，IF 8.0385，中科院大类一区)；
14）Congjun Xu#, Haolan Yang#, Tao Zhang, Zilin Guan, Jie Chen, Hualu Lai, Xiaoyu Xu, Yanjuan Huang, Zeqian Huang, Chunshun Zhao* Reduction-responsive Dehydroepiandrosterone Prodrug Nanoparticles Loaded with Camptothecin for Cancer Therapy by Enhancing Oxidation Therapy and Cell Replication Inhibition. International Journal of Pharmaceutics. 2021, 603, 120671 (SCI，IF 5.875, 中科院大类二区，药学一区)。
欢迎对科研满怀热情的药学、生物学、基础医学相关人才加入。
欢迎具有药学、化学、生物学背景的同学报考本课题组研究生。
